Issue 9, 2022, Issue in Progress
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RSC Advances

Comment on “Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review” by R. Obaid, E. Mughal, N. Naeem, A. Sadiq, R. Alsantali, R. Jassas, Z. Moussa and S. Ahmed, RSC Advances, 2021, 11, 22159

Hubert Wojtaseka  

a Institute of Chemistry, Opole University, Ul. Oleska 48, 45-052 Opole, Poland
E-mail: Hubert.Wojtasek@uni.opole.pl
Fax: +48 77 452 7101
Tel: +48 77 452 7122

Abstract

A review article has been published recently (RSC Advances, 2021, 11, 22159–22198) describing flavonoids as inhibitors of tyrosinase. However, many compounds included in this review have been previously shown to act as substrates of this enzymes or antioxidants reducing tyrosinase-generated o-quinones. Products of their oxidation absorb light in a range different than dopachrome, the oxidation product of L-tyrosine or L-dopa, whose concentration is measured spectrophotometrically in the standard enzymatic assay to monitor the activity of this enzyme. This effect is interpreted as enzyme inhibition, which, in fact, is only apparent and results from inadequate methodology.

Graphical abstract: Comment on “Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review” by R. Obaid, E. Mughal, N. Naeem, A. Sadiq, R. Alsantali, R. Jassas, Z. Moussa and S. Ahmed, RSC Advances, 2021, 11, 22159

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Article information

DOI
https://doi.org/10.1039/D1RA08162D
Article type
Comment
Submitted
07 Nov 2021
Accepted
19 Jan 2022
First published
14 Feb 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 5395-5397

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Comment on “Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review” by R. Obaid, E. Mughal, N. Naeem, A. Sadiq, R. Alsantali, R. Jassas, Z. Moussa and S. Ahmed, RSC Advances, 2021, 11, 22159

H. Wojtasek, RSC Adv., 2022, 12, 5395 DOI: 10.1039/D1RA08162D

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