Issue 10, 2022
From the journal:

Organic & Biomolecular Chemistry

Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles

Anjali Dahiya, ORCID logo a   Ashish Kumar Sahoo, ORCID logo a   Nikita Chakraborty,a   Bubul Das ORCID logo a  and  Bhisma K. Patel ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Guwahati, Assam, India
E-mail: patel@iitg.ac.in

Abstract

Hypervalent iodine (HVI) chemistry is a rapidly growing subdomain of contemporary organic chemistry because of its enormous synthetic applications. The high nucleofugality of the phenyliodonio group (–I+Ph) and its radical nature, serving as a single-electron oxidant makes HVI compounds highly valuable in organic synthesis. Due to the feasibility and benignity, reactions that rely solely on HVI reagents as promoters have received particular interest. Considering their great influence and synthetic potential, we contribute a brief synopsis on this field with a specific emphasis on metal-free functionalisations of alkenes, alkynes and heterocycles. The discussion is divided according to the type of substrate and reaction type and elaborated with mechanism and representative examples.

Graphical abstract: Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles

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DOI
https://doi.org/10.1039/D1OB02233D
Article type
Review Article
Submitted
15 Nov 2021
Accepted
17 Jan 2022
First published
19 Jan 2022

Org. Biomol. Chem., 2022,20, 2005-2027

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Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles

A. Dahiya, A. K. Sahoo, N. Chakraborty, B. Das and B. K. Patel, Org. Biomol. Chem., 2022, 20, 2005 DOI: 10.1039/D1OB02233D

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