A porphyrin-based metallacage for enhanced photodynamic therapy

Jingjing Jiao; Jing He; Mengmeng Li; Jingxia Yang; Hong Yang; Xiaoqing Wang; Shiping Yang

doi:10.1039/D1NR08293K

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A porphyrin-based metallacage for enhanced photodynamic therapy†

Jingjing Jiao,

^a Jing He,^a Mengmeng Li,^a Jingxia Yang,^a Hong Yang,

^a Xiaoqing Wang

*^b and Shiping Yang

*^a

Author affiliations

* Corresponding authors

^a The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai 200234, China
E-mail: shipingy@shnu.edu.cn

^b Department of Chemistry, College of Science, North University of China, Taiyuan 030051, China
E-mail: xqwang@nuc.edu.cn

Abstract

In this study, we designed an effective nanoplatform to improve the photodynamic therapy (PDT) of porphyrins. Combining a porphyrin-based metallacage (PM), hyaluronidase (HAase) and DSPE-mPEG2000 together, the nanoparticle (PM@HAase-mPEG) showed enhanced PDT efficacy. The PM improved the stability of the porphyrin, avoided its aggregation and provided cavities to concentrate oxygen molecules, which was beneficial for enhancing PDT. HAase degraded HA to increase the intracellular accumulation of nanoparticles, normalized blood vessels and relieved hypoxia in tumors. PM@HAase-mPEG inhibited the growth of tumors in a 4T1 mouse model by the generated singlet oxygen with excellent PDT efficacy. This study resolved the problems of the instability of PSs, less cellular accumulation of drugs, and tumor hypoxia that limited the anti-tumor application of PDT.

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Article information

DOI: https://doi.org/10.1039/D1NR08293K
Article type: Paper
Submitted: 17 Dec 2021
Accepted: 10 Mar 2022
First published: 10 Mar 2022

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Nanoscale, 2022,14, 6373-6383

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A porphyrin-based metallacage for enhanced photodynamic therapy

J. Jiao, J. He, M. Li, J. Yang, H. Yang, X. Wang and S. Yang, Nanoscale, 2022, 14, 6373 DOI: 10.1039/D1NR08293K

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A porphyrin-based metallacage for enhanced photodynamic therapy†

Abstract

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A porphyrin-based metallacage for enhanced photodynamic therapy

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