SCHEDULED MAINTENANCE
PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity†
a
Yubo
Wang,
a
Tomohisa
Watanabe,
a
Shuya
Uno,
a
Masatoshi
Maeki,
b
Manabu
Tokeshi,
b
Takuya
Isono,
b
Kenji
Tajima,
b
Toshifumi
Satoh,
b
Shin-ichiro
Sato,
b
Yutaka
Miura
c
and
Takuya
Yamamoto
*b
Abstract
Silver nanoparticles (AgNPs) are practically valuable in biological applications. However, no steady PEGylation has been established, which is essential for internal use in humans or animals. In this study, cyclic PEG (c-PEG) without any chemical inhomogeneity is physisorbed onto AgNPs to successfully PEGylate and drastically enhance the dispersion stability against physiological conditions, white light, and high temperature. In contrast, linear HO–PEG–OH and MeO–PEG–OMe do not confer stability to AgNPs, and HS–PEG–OMe, which is often used for gold nanoparticles, sulfidates the surface to considerably degrade the properties. TEM shows an essentially intact nanostructure of c-PEG-physisorbed AgNPs even after heating at 95 °C, while complete disturbance is observed for other AgNPs. Molecular weight- and concentration-dependent stabilization by c-PEG is investigated, and DLS and ζ-potential measurements prove the formation of a c-PEG layer on the surface of AgNPs. Furthermore, c-PEG-physisorbed AgNPs exhibit persistent antimicrobial activity and cytotoxicity.
- This article is part of the themed collection: Popular Advances
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