Issue 2, 2022
From the journal:

Chemical Communications

Construction of a two-dimensional DNA–RNA hybridized membrane for collecting tumor-derived exosomes†

Yoonbin Ji,a   Dajeong Kim, ORCID logo a   Hyejin Kim,a   Sangwoo Hana  and  Jong Bum Lee ORCID logo *a  

* Corresponding authors

a Department of Chemical Engineering, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-gu, Seoul 02504, Republic of Korea
E-mail: jblee@uos.ac.kr

Abstract

Macroscopic nucleic acid-based structures have attracted much attention in biomedical fields. Here, we introduce a novel DNA–RNA hybridized membrane structure via enzymatic dual polymerization. The membrane exhibited enhanced rigidity and functionality. Encoded with an aptamer, the membrane showed great potential as a collecting platform of tumor-derived exosomes without additional labeling.

Graphical abstract: Construction of a two-dimensional DNA–RNA hybridized membrane for collecting tumor-derived exosomes

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Article information

DOI
https://doi.org/10.1039/D1CC05924F
Article type
Communication
Submitted
20 Oct 2021
Accepted
30 Nov 2021
First published
04 Dec 2021

Chem. Commun., 2022,58, 266-269

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Construction of a two-dimensional DNA–RNA hybridized membrane for collecting tumor-derived exosomes

Y. Ji, D. Kim, H. Kim, S. Han and J. B. Lee, Chem. Commun., 2022, 58, 266 DOI: 10.1039/D1CC05924F

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