Issue 97, 2021
From the journal:

Chemical Communications

Detecting Mycobacterium Tuberculosis using a nitrofuranyl calanolide–trehalose probe based on nitroreductase Rv2466c†

Xueyuan Li,‡ab   Pengfei Geng,‡a   Xiaoqiao Hong,‡a   Zhaogang Sun*cd  and  Gang Liu ORCID logo *a  

* Corresponding authors

a School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China
E-mail: gangliu27@tsinghua.edu.cn

b Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China

c Translational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
E-mail: sunzg75@163.com

d Beijing Key Laboratory in Drug Resistant Tuberculosis Research, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China

Abstract

A new Mtb fluorescent probe, NFC-Tre-5, was reported that could label single cells of Mtb under various stress conditions via a unique fluorescence off–on feature by a Rv2466c-mediated reductive mechanism. This probe effectively facilitates the rapid and specific detection of Mtb in the host cell during infection and the detection of Mtb in sputum samples from patients.

Graphical abstract: Detecting Mycobacterium Tuberculosis using a nitrofuranyl calanolide–trehalose probe based on nitroreductase Rv2466c

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Article information

DOI
https://doi.org/10.1039/D1CC05187C
Article type
Communication
Submitted
14 Sep 2021
Accepted
16 Nov 2021
First published
17 Nov 2021

Chem. Commun., 2021,57, 13174-13177

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Detecting Mycobacterium Tuberculosis using a nitrofuranyl calanolide–trehalose probe based on nitroreductase Rv2466c

X. Li, P. Geng, X. Hong, Z. Sun and G. Liu, Chem. Commun., 2021, 57, 13174 DOI: 10.1039/D1CC05187C

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