An ICT-based fluorescence enhancement probe for detection of Sn2+ in cancer cells

Xiangying Meng; Lai You; Siyuan Li; Qi Sun; Xiaogang Luo; Haifeng He; Jinglan Wang; Feng Zhao

doi:10.1039/D0RA07330J

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An ICT-based fluorescence enhancement probe for detection of Sn²⁺ in cancer cells†

Xiangying Meng,^a Lai You,^a Siyuan Li,^a Qi Sun,

^b Xiaogang Luo,^bc Haifeng He,

*^a Jinglan Wang*^a and Feng Zhao*^a

Author affiliations

* Corresponding authors

^a Jiangxi Engineering Laboratory of Waterborne Coating, School of Chemistry and Chemical Engineering, Jiangxi Science and Technology Normal University, Nanchang 330013, People's Republic of China
E-mail: hehf0427@jxstnu.com.cn, jxncwjl@163.com, zhf19752003@163.com

^b Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, PR China

^c School of Materials Science and Engineering, Zhengzhou University, No. 100 Science Avenue, Zhengzhou City 450001, Henan Province, PR China

Abstract

Development of a novel fluorescence enhancement probe for detection of Sn²⁺ in organisms, with high selectivity and sensitivity, is of great interest but remains a great challenge. Herein, an ICT-based fluorescence probe TPPB was rationally developed to act as an ‘enhancement’ luminescent and “naked-eye” indicator for Sn²⁺ detection. Importantly, spectroscopic studies indicated that TPPB was a fluorescence enhancement sensor for Sn²⁺ with rapid response, low detection limit (0.116 μM) and excellent binding constant (1.6 × 10⁴ M⁻¹). The mechanism of TPPB response to Sn²⁺ was further proved by ¹H NMR titration, and enhancement calculations. Furthermore, TPPB is applied as a fluorescence probe for imaging in Hela cells, indicated that it can be potentially applied for Sn²⁺ sensing in biological fields.

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Article information

DOI: https://doi.org/10.1039/D0RA07330J
Article type: Paper
Submitted: 26 Aug 2020
Accepted: 07 Oct 2020
First published: 13 Oct 2020
This article is Open Access

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RSC Adv., 2020,10, 37735-37742

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An ICT-based fluorescence enhancement probe for detection of Sn²⁺ in cancer cells

X. Meng, L. You, S. Li, Q. Sun, X. Luo, H. He, J. Wang and F. Zhao, RSC Adv., 2020, 10, 37735 DOI: 10.1039/D0RA07330J

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