Recent progress in chemical approaches for the development of novel neuraminidase inhibitors

Ahmed Mahal; Meitao Duan; Dhafer S. Zinad; Ranjan K. Mohapatra; Ahmad J. Obaidullah; Xiaoyi Wei; Manoj K. Pradhan; Debadutta Das; Venkataramana Kandi; Hany S. Zinad; Quanhong Zhu

doi:10.1039/D0RA07283D

Recent progress in chemical approaches for the development of novel neuraminidase inhibitors

Ahmed Mahal,

*^abl Meitao Duan,^cd Dhafer S. Zinad,

^e Ranjan K. Mohapatra,

*^f Ahmad J. Obaidullah,^gm Xiaoyi Wei,^b Manoj K. Pradhan,^f Debadutta Das,

^h Venkataramana Kandi,ⁱ Hany S. Zinad^jk and Quanhong Zhu*^cd

Author affiliations

* Corresponding authors

^a Department of Medical Biochemical Analysis, College of Health Technology, Cihan University-Erbil, Kurdistan Region, Erbil, Iraq
E-mail: ahmed.mahal@cihanuniversity.edu.iq

^b Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, Chinese Academy of Sciences, South China Botanical Garden, Guangzhou 510650, People's Republic of China

^c School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China
E-mail: zqh@smu.edu.cn

^d Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, People's Republic of China

^e Applied Science Department, University of Technology, Baghdad 10001, Iraq

^f Department of Chemistry, Government College of Engineering, Keonjhar, Odisha 758002, India
E-mail: ranjank_mohapatra@yahoo.com

^g Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

^h Department of Chemistry, Sukanti Degree College, Subarnapur, Odisha 767017, India

ⁱ Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, Telangana, India

^j Biosciences Institute, Faculty of Medical Science, Newcastle University, Newcastle upon Tyne, UK

^k Iraq Natural History Museum and Research Centre (INHM), University of Baghdad, Baghdad, Iraq

^l Guangzhou HC Pharmaceutical Co., Ltd, Guangzhou 510663, People's Republic of China

^m Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Abstract

Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are reagents used to block the enzyme called neuraminidase to prevent the influenza infection from spreading. Neuraminidase inhibitors are widely used in the treatment of influenza infection, but still there is a need to develop more potent agents for the more effective treatment of influenza. Complications of the influenza disease lead to death, and one of these complications is drug resistance; hence, there is an urgent need to develop more effective agents. This review focuses on the recent advances in chemical synthesis pathways used for the development of new neuraminidase agents along with the medicinal aspects of chemically modified molecules, including the structure–activity relationship, which provides further rational designs of more active small molecules.

This article is part of the themed collection: 2021 Reviews in RSC Advances

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Recent progress in chemical approaches for the development of novel neuraminidase inhibitors

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