SCHEDULED MAINTENANCE
Lauren E.
Hatcher, 
*ab
Chick C.
Wilson
ac
*ab
Chick C.
Wilson
ac
Abstract
Two workflows are presented that are relevant to the design and construction of end-to-end pharmaceutical manufacturing processes. The workflows target the very early stage crystallisation aspect of these processes – production of the primary crystalline solid form – and relate to establishing decision-driven approaches for the screening for multi-component forms, specifically co-crystals, and to the use of additives to control crystal and primary particle form, notably morphology. These workflows are shown to benefit from the use of the million-plus structures in the Cambridge structural database and the associated structural informatics and analysis tools and are placed into the context of the work of the CMAC Future Manufacturing Hub.
- This article is part of the themed collection: The Cambridge Structural Database - A wealth of knowledge gained from a million structures
Please wait while we load your content...
