Issue 22, 2021
From the journal:

Chemical Communications

Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting†

Zhaobao Zhang, ORCID logo a   Chunling Tang,b   Roel Hammink, ORCID logo cd   Frank H. T. Nelissen,a   Hans A. Heus ORCID logo *a  and  Paul H. J. Kouwer ORCID logo *a  

* Corresponding authors

a Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
E-mail: p.kouwer@science.ru.nl

b Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands

c Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands

d Division of Immunotherapy, Oncode Institute, Radboud University Medical Center, Nijmegen, The Netherlands

Abstract

T-cell acute lymphoblastic leukemia causes a disproportional amount of immature white blood cells in the patients’ bone marrow. The significant undesired side effects associated with traditional chemotherapy treatment prompted us to study a more effective treatment strategy. We decorated polyisocyanopeptide scaffolds with the selective leukemia cell binding aptamer sgc8c and found that the polymers inhibit proliferation by G0/G1-phase arrest, serving as an opportunity for future therapeutic strategies.

Graphical abstract: Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

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Article information

DOI
https://doi.org/10.1039/D0CC08205H
Article type
Communication
Submitted
17 Dec 2020
Accepted
04 Feb 2021
First published
04 Feb 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 2744-2747

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Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

Z. Zhang, C. Tang, R. Hammink, F. H. T. Nelissen, H. A. Heus and P. H. J. Kouwer, Chem. Commun., 2021, 57, 2744 DOI: 10.1039/D0CC08205H

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