Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform

Chi-An Cheng; Wei Chen; Le Zhang; Holden H. Wu; Jeffrey I. Zink

doi:10.1039/D0CC03179H

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Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform†

Chi-An Cheng,

^ab Wei Chen,

^bc Le Zhang,

^d Holden H. Wu

*^ad and Jeffrey I. Zink

*^bc

Author affiliations

* Corresponding authors

^a Department of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, USA
E-mail: HoldenWu@mednet.ucla.edu

^b California NanoSystems Institute, University of California Los Angeles, California 90095, USA
E-mail: zink@chem.ucla.edu

^c Department of Chemistry & Biochemistry, University of California Los Angeles, Los Angeles, California 90095, USA

^d Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA

Abstract

We developed a theranostic approach exemplifying a concept called an “exchange method” that controls and “images” drug release from nanoparticles using magnetic resonance imaging-guided high-intensity focused ultrasound. The controllable amount of released drug and therapeutic efficacy can be self-reported by associated MRI contrast changes in solution and in cells.

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Article information

DOI: https://doi.org/10.1039/D0CC03179H
Article type: Communication
Submitted: 03 May 2020
Accepted: 24 Jul 2020
First published: 24 Jul 2020

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Chem. Commun., 2020,56, 10297-10300

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Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform

C. Cheng, W. Chen, L. Zhang, H. H. Wu and J. I. Zink, Chem. Commun., 2020, 56, 10297 DOI: 10.1039/D0CC03179H

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Chemical Communications

Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform†

Abstract

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Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform

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