Issue 15, 2020, Issue in Progress
From the journal:

RSC Advances

Biomimetic enzyme barrier for preventing intestine-derived LPS induced diseases†

Cheng Zhao, ORCID logo abc   Xiaoming Kao,a   Zhiwei Wang,ab   Qinjie Liu,ab   Jie Wu,ab   Qiongyuan Hu,ab   Xiuwen Wu*ab  and  Jianan Ren ORCID logo *ab  

* Corresponding authors

a Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
E-mail: lygwxw@163.com, jiananr@gmail.com

b Lab for Trauma and Surgical Infection, Jinling Hospital, Nanjing, China

c Department of Endocrinology, Xiangya Shenzhen Endocrinology and Metabolism Center, The First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China

Abstract

Biomimetic enzyme barrier (BEB) encapsulated microcapsules with alginate shells were in situ fabricated with a microfluidic electrospray approach for preventing intestine-derived LPS induced diseases. As the alginate shells could protect the contents in gastric juice and release them in the intestine, the inner BEB could form a consecutive immune barrier on the surface of the intestine during the release. Through combining BEB with alkaline phosphatase, the immune barrier could degrade and prevent the permeation of lipopolysaccharide, which enhanced the intestinal barrier function. Thus, the BEB microcapsules were imparted with outstanding ability in preventing intestine-derived LPS induced diseases. Based on an in vivo study, we demonstrated that this BEB microcapsule could effectively protect organ function, restore intestinal barrier integrity, prevent the permeation of LPS and alleviate inflammation. Therefore, the generated microcapsules have potential for clinical applications.

Graphical abstract: Biomimetic enzyme barrier for preventing intestine-derived LPS induced diseases

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9RA08721D
Article type
Paper
Submitted
24 Oct 2019
Accepted
03 Feb 2020
First published
03 Mar 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 9126-9132

Permissions

Request permissions

Biomimetic enzyme barrier for preventing intestine-derived LPS induced diseases

C. Zhao, X. Kao, Z. Wang, Q. Liu, J. Wu, Q. Hu, X. Wu and J. Ren, RSC Adv., 2020, 10, 9126 DOI: 10.1039/C9RA08721D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements