Issue 7, 2020, Issue in Progress

Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Abstract

Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(N-vinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.

Graphical abstract: Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Article information

Article type
Paper
Submitted
25 Aug 2019
Accepted
09 Dec 2019
First published
23 Jan 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 3926-3930

Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

B. Ozkahraman, K. Emeriewen, G. M. Saleh and N. T. K. Thanh, RSC Adv., 2020, 10, 3926 DOI: 10.1039/C9RA06712D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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