Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery

Shengran Li; Lin Lin; Wenliang Wang; Xinxin Yan; Binggang Chen; Sangni Jiang; Sanrong Liu; Xiaojing Ma; Huayu Tian; Xifei Yu

doi:10.1039/C9CC10041E

Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery†

Shengran Li,‡^ab Lin Lin,‡^c Wenliang Wang,

^d Xinxin Yan,^ab Binggang Chen,^ab Sangni Jiang,^ab Sanrong Liu,*^a Xiaojing Ma,

*^a Huayu Tian

^bc and Xifei Yu

*^ab

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* Corresponding authors

^a Laboratory of Polymer Composites Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
E-mail: liusanrong@ciac.ac.cn, xjma@ciac.ac.cn, xfyu@ciac.ac.cn

^b University of Science and Technology of China, Hefei, Anhui 230026, China

^c Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China

^d Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Abstract

We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI_25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.

Chemical Communications

Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery†

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Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery

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