Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: activation of C–O bonds

Yasuaki Iyori; Kenjiro Takahashi; Ken Yamazaki; Yusuke Ano; Naoto Chatani

doi:10.1039/C9CC07710C

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Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: activation of C–O bonds†

Yasuaki Iyori,‡^a Kenjiro Takahashi,^a Ken Yamazaki,^a Yusuke Ano

^a and Naoto Chatani

*^a

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* Corresponding authors

^a Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
E-mail: chatani@chem.eng.osaka-u.ac.jp

Abstract

The nickel-catalyzed reductive cleavage of esters in the absence of an external reductant, which involves the cleavage of an inert acyl C–O bond in O-alkyl esters is reported. Various groups, such as N-containing heterocycles, esters, amides, and even arene rings can function as a directing group.

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Article information

DOI: https://doi.org/10.1039/C9CC07710C
Article type: Communication
Submitted: 01 Oct 2019
Accepted: 21 Oct 2019
First published: 22 Oct 2019

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Chem. Commun., 2019,55, 13610-13613

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Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: activation of C–O bonds

Y. Iyori, K. Takahashi, K. Yamazaki, Y. Ano and N. Chatani, Chem. Commun., 2019, 55, 13610 DOI: 10.1039/C9CC07710C

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Chemical Communications

Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: activation of C–O bonds†

Abstract

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Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: activation of C–O bonds

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