Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

Ranjan Sasmal; Nilanjana Das Saha; Florian Schueder; Divyesh Joshi; Vasu Sheeba; Ralf Jungmann; Sarit S. Agasti

doi:10.1039/C9CC07153A

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Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging†

Ranjan Sasmal,^a Nilanjana Das Saha,^ab Florian Schueder,^cd Divyesh Joshi,^e Vasu Sheeba,

^f Ralf Jungmann

^cd and Sarit S. Agasti

*^ab

Author affiliations

* Corresponding authors

^a New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India
E-mail: sagasti@jncasr.ac.in

^b Chemistry & Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

^c Max Planck Institute of Biochemistry, 82152 Martinsried near Munich, Germany

^d Department of Physics and Center for Nanoscience, Ludwig Maximillian University, 80539 Munich, Germany

^e Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

^f Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

Abstract

Synthetic host–guest complexes are inherently dynamic as they employ weak and reversible noncovalent interactions for their recognition processes. We strategically exploited dynamic supramolecular recognition between fluorescently labeled guest molecules to complementary cucurbit[7]uril hosts to obtain stochastic switching between fluorescence ON- and OFF-states, enabling PAINT-based nanoscopic imaging in cells and tissues.

This article is part of the themed collection: Cucurbiturils and related cavitands

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DOI: https://doi.org/10.1039/C9CC07153A
Article type: Communication
Submitted: 12 Sep 2019
Accepted: 29 Oct 2019
First published: 06 Nov 2019

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Chem. Commun., 2019,55, 14430-14433

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Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

R. Sasmal, N. Das Saha, F. Schueder, D. Joshi, V. Sheeba, R. Jungmann and S. S. Agasti, Chem. Commun., 2019, 55, 14430 DOI: 10.1039/C9CC07153A

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Chemical Communications

Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging†

Abstract

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Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

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