Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source

Xiaoxia Yu; Yao Zhou; Xingxing Ma; Qiuling Song

doi:10.1039/C9CC03534F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source†

Xiaoxia Yu,^a Yao Zhou,

^a Xingxing Ma^a and Qiuling Song

*^ab

Author affiliations

* Corresponding authors

^a Institute of Next Generation Matter Transformation, College of Chemical Engineering and College of Materials Science & Engineering at Huaqiao University, Xiamen, Fujian, P. R. China
E-mail: qsong@hqu.edu.cn

^b College of Chemistry, Fuzhou University, Fuzhou, Fujian, China

Abstract

An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The desired symmetric and unsymmetric 2,4-disubstituted-1,3,5-triazines were obtained in decent yields via multiple C–N bond formation, in which ethyl bromodifluoroacetate is harnessed as a unique C1 synthon via quadruple cleavage. This reaction is transition metal-free, oxidant-free and simple in operation, and only lowly toxic inorganic wastes are generated.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C9CC03534F
Article type: Communication
Submitted: 07 May 2019
Accepted: 10 Jun 2019
First published: 10 Jun 2019

Download Citation

Chem. Commun., 2019,55, 8079-8082

Permissions

Request permissions

Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source

X. Yu, Y. Zhou, X. Ma and Q. Song, Chem. Commun., 2019, 55, 8079 DOI: 10.1039/C9CC03534F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source

Social activity

Search articles by author

Spotlight

Advertisements