Issue 56, 2019
From the journal:

Chemical Communications

A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: development and cellular applicability in epigenetic studies†

Masaya Mori,a   Yuuta Fujikawa, ORCID logo *a   Manami Kikkawa, ORCID logo a   Moeho Shino, ORCID logo a   Mei Sawane, ORCID logo a   Shiho Sato ORCID logo a  and  Hideshi Inoue ORCID logo a  

* Corresponding authors

a School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, Japan
E-mail: yfuji@toyaku.ac.jp

Abstract

Pi-class glutathione S-transferase (GSTP1) is a molecular marker enzyme whose expression level is altered in various malignant tumour tissues. Herein, we report the first highly selective fluorogenic GSTP1 substrate, Ps-TG, and its membrane-permeable derivative Ps-TAc, for specific visualization of intracellular GSTP1 activity in cancer cells or epigenetically regulated GSTP1 expression.

Graphical abstract: A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: development and cellular applicability in epigenetic studies

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Article information

DOI
https://doi.org/10.1039/C9CC03064F
Article type
Communication
Submitted
19 Apr 2019
Accepted
12 Jun 2019
First published
12 Jun 2019

Chem. Commun., 2019,55, 8122-8125

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A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: development and cellular applicability in epigenetic studies

M. Mori, Y. Fujikawa, M. Kikkawa, M. Shino, M. Sawane, S. Sato and H. Inoue, Chem. Commun., 2019, 55, 8122 DOI: 10.1039/C9CC03064F

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