Issue 37, 2019
From the journal:

Chemical Communications

Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis†

Thomas M. Haas,ab   Paul Ebensperger,ab   Verena B. Eisenbeis, ORCID logo ab   Christoph Nopper,ab   Tobias Dürr, ORCID logo ab   Nikolaus Jork,ab   Nicole Steck, ORCID logo ab   Claudia Jessen-Trefzerc  and  Henning J. Jessen ORCID logo *ab  

* Corresponding authors

a CIBSS – Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany
E-mail: henning.jessen@ocbc.uni-freiburg.de

b Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg, Germany

c Institute of Pharmaceutical Biology, University of Freiburg, 79104 Freiburg, Germany

Abstract

A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.

Graphical abstract: Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

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Article information

DOI
https://doi.org/10.1039/C9CC01688K
Article type
Communication
Submitted
28 Feb 2019
Accepted
08 Apr 2019
First published
08 Apr 2019

Chem. Commun., 2019,55, 5339-5342

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Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

T. M. Haas, P. Ebensperger, V. B. Eisenbeis, C. Nopper, T. Dürr, N. Jork, N. Steck, C. Jessen-Trefzer and H. J. Jessen, Chem. Commun., 2019, 55, 5339 DOI: 10.1039/C9CC01688K

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