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Modular synthesis and modification of novel bifunctional dendrons†
Abstract
Herein, we report the design and synthesis of two novel bifunctional dendrons bearing multiple amine termini at the periphery and an azide at the focal point. Copper-catalyzed alkyne–azide cycloaddition enabled modular dendritic scaffold assembly resulting in a first generation dendron carrying six amines and a second generation dendron carrying eighteen amines. Peripheral amines were labeled with multiple copies of a metal isotope, whereas the azide functionality at the focal point was employed in conjugation to a single anti-human CD4 antibody. We demonstrated that the highly monomeric first generation dendron–antibody conjugate selectively detected CD4+ T cells in the PMBC culture.
- This article is part of the themed collection: Chemical Biology in OBC
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