Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

Tian Zhong; Jia Fu; Ran Huang; Lianjiang Tan

doi:10.1039/C7RA02997G

Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

Tian Zhong,^a Jia Fu,^a Ran Huang*^b and Lianjiang Tan

*^c

Author affiliations

* Corresponding authors

^a Department of Chemistry and Pharmacy, Zhuhai College of Jilin University, Zhuhai 519041, Guangdong, China

^b State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
E-mail: ranhuang84@outlook.com

^c Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
E-mail: ljtan@sjtu.edu.cn
Tel: +86-21-34204561

Abstract

CuS nanoparticles capped with a long-chain carboxylic acid were synthesized and conjugated with chitosan (CS) via N-hydroxysuccinimide. The anticancer drug doxorubicin (DOX) was then encapsulated by hydrophobic interaction, producing pH-responsive CuS(DOX)@CS nanospheres with photothermal conversion properties for controllable drug release and photothermal ablation (PTA). On the one hand, the encapsulated CuS nanoparticles can absorb NIR photons and be heated efficiently. On the other hand, the entrapped DOX can be released from the swollen CuS(DOX)@CS nanospheres caused by stretched oleoyl-CS chains at lowered pH. Combining chemotherapy and PTA, the biocompatible CuS(DOX)@CS nanospheres can provide synergistic cancer treatment, as evidenced by both in vitro and in vivo experiments. This study gives new insights into developing multifunctional drug delivery agents for cancer nanotherapeutics.

Article information

https://doi.org/10.1039/C7RA02997G

Article type

Paper

Submitted

13 Mar 2017

Accepted

04 May 2017

First published

18 May 2017

This article is Open Access

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RSC Adv., 2017,7, 26640-26649

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Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

T. Zhong, J. Fu, R. Huang and L. Tan, RSC Adv., 2017, 7, 26640 DOI: 10.1039/C7RA02997G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

Abstract

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Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

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