Issue 13, 2018
From the journal:

Chemical Communications

Evolutionary selection of personalized melanoma cell/tissue dual-homing peptides for guiding bionanofibers to malignant tumors†

Mingying Yang,‡*a   Yan Li,‡b   Yanyan Huai,b   Chenyuan Wang,c   Wenfang Yid  and  Chuanbin Mao ORCID logo *be  

* Corresponding authors

a Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Yuhangtang Road 866, Zhejiang, China
E-mail: yangm@zju.edu.cn

b Depatment of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Sciences Research Center, Norman, OK, USA
E-mail: cbmao@ou.edu

c Sun Yat-sen University Cancer Center, 651 Dongfeng Road East Guangzhou, Guangdong, China

d Department of Pediatrics, Zhuhai People's Hospital, Jinan University, Zhuhai, Guangdong, China

e School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China

Abstract

Both melanoma cells and tissues were allowed to interact with an identical pool of billions of human-safe phage nanofiber clones with each genetically displaying a unique 12-mer peptide at the tips, respectively, resulting in the discovery of bionanofibers displaying a melanoma cell/tissue dual-homing peptide for personalized targeted melanoma therapy.

Graphical abstract: Evolutionary selection of personalized melanoma cell/tissue dual-homing peptides for guiding bionanofibers to malignant tumors

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Article information

DOI
https://doi.org/10.1039/C7CC09077C
Article type
Communication
Submitted
25 Nov 2017
Accepted
16 Jan 2018
First published
26 Jan 2018

Chem. Commun., 2018,54, 1631-1634

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Evolutionary selection of personalized melanoma cell/tissue dual-homing peptides for guiding bionanofibers to malignant tumors

M. Yang, Y. Li, Y. Huai, C. Wang, W. Yi and C. Mao, Chem. Commun., 2018, 54, 1631 DOI: 10.1039/C7CC09077C

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