Difunctional fluorescent HSA modified CoFe2O4 magnetic nanoparticles for cell imaging

Qianfang Yao; Yang Zheng; Wenyu Cheng; MengJun Chen; Jie Shen; Meizhen Yin

doi:10.1039/C6TB01787H

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Difunctional fluorescent HSA modified CoFe₂O₄ magnetic nanoparticles for cell imaging†

Qianfang Yao,^a Yang Zheng,^b Wenyu Cheng,^a MengJun Chen,^a Jie Shen^b and Meizhen Yin*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers of Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, 100029 Beijing, China
E-mail: yinmz@mail.buct.edu.cn

^b Department of Entomology, China Agricultural University, 100193 Beijing, China

Abstract

Difunctional fluorescent CoFe₂O₄ magnetic nanoparticles were prepared through a facile method. After the absorption of dopamine, human serum albumin (HSA) was easily attached onto the surface of CoFe₂O₄ magnetic nanoparticles through a reversible non-covalent bond between HSA and –NH₂ in dopamine. With the same type of interaction, the designed perylene diimide (PDI) based –NH₂ rich fluorescent molecule (PDI-4NH₂) was decorated on the HSA-modified CoFe₂O₄ nanoparticles. The produced fluorescent magnetic nanoparticles exhibited great biocompatibility and could successfully enter the cell. Therefore, we have developed a novel method to obtain fluorescent magnetic nanoparticles with potential biomedical applications.

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Article information

DOI: https://doi.org/10.1039/C6TB01787H
Article type: Paper
Submitted: 16 Jul 2016
Accepted: 30 Aug 2016
First published: 30 Aug 2016

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J. Mater. Chem. B, 2016,4, 6344-6349

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Difunctional fluorescent HSA modified CoFe₂O₄ magnetic nanoparticles for cell imaging

Q. Yao, Y. Zheng, W. Cheng, M. Chen, J. Shen and M. Yin, J. Mater. Chem. B, 2016, 4, 6344 DOI: 10.1039/C6TB01787H

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Journal of Materials Chemistry B