Issue 98, 2016, Issue in Progress
From the journal:

RSC Advances

Sensing of tryptophan by a non-toxic cobalt(ii) complex†

Swapan Kumar Jana,a   Amit Kumar Mandal,b   Anoop Kumar,c   Horst Puschmann,d   Maidul Hossain*a  and  Sudipta Dalai*a  

* Corresponding authors

a Department of Chemistry & Chemical Technology, Vidyasagar University, W. B., India
E-mail: sudipta@mail.vidyasagar.ac.in, hossainm@mail.vidyasagar.ac.in

b Department of Microbiology, Vidyasagar University, W. B., India

c Department of Biotechnology, University of North Bengal, W. B., India

d Department of Chemistry, University of Durham, Durham DH13LE, UK

Abstract

A non-toxic, hemocompatible, fluorescent probe as cobalt(II) based complex [Co(PS)4](ClO4)2 (1) (PS: N-pyridylsalicylaldimine) was successfully synthesized and characterised by single crystal X-ray diffraction studies. The structural analysis revealed that 1 exhibits intramolecular π–π interaction. The recognition ability of 1 towards various amino acids and proteins were studied by UV-vis and fluorescence spectroscopy. The titled complex selectively sense the Trp by reducing its internal fluorescence quenching. It also sense BSA with a detection limit of 56 nM. The binding constant of 1 was analysed by Hill's equation and it was found that it binds to Trp and BSA in the order of 103 and 104 respectively.

Graphical abstract: Sensing of tryptophan by a non-toxic cobalt(ii) complex

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Article information

DOI
https://doi.org/10.1039/C6RA16086G
Article type
Paper
Submitted
21 Jun 2016
Accepted
25 Sep 2016
First published
03 Oct 2016

RSC Adv., 2016,6, 95888-95896

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Sensing of tryptophan by a non-toxic cobalt(II) complex

S. K. Jana, A. K. Mandal, A. Kumar, H. Puschmann, M. Hossain and S. Dalai, RSC Adv., 2016, 6, 95888 DOI: 10.1039/C6RA16086G

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