Issue 37, 2016, Issue in Progress
From the journal:

RSC Advances

Dynamic electrochemical quantitation of dopamine release from a cells-on-paper system†

Raphaël Trouillon*a  and  Martin A. M. Gijsa  

* Corresponding authors

a Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
E-mail: raphael.trouillon@m4x.org

Abstract

A hybrid microfluidic/electrochemical system is described for the time-resolved detection of dopamine (DA) from neuron-like PC12 cells cultured on a patch of filter paper. Cell adherence to the surface of the paper is investigated using fluorescence microscopy. DA release after stimulation with acetylcholine, in the presence or absence of drugs, is studied. Overall, the results obtained with this system are in good agreement with single cell data, thus demonstrating the validity of our approach for higher-throughput quantitative chemical analyses on tissue or organs-on-a-chip.

Graphical abstract: Dynamic electrochemical quantitation of dopamine release from a cells-on-paper system

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Article information

DOI
https://doi.org/10.1039/C6RA02487D
Article type
Communication
Submitted
27 Jan 2016
Accepted
12 Mar 2016
First published
14 Mar 2016

RSC Adv., 2016,6, 31069-31073

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Dynamic electrochemical quantitation of dopamine release from a cells-on-paper system

R. Trouillon and M. A. M. Gijs, RSC Adv., 2016, 6, 31069 DOI: 10.1039/C6RA02487D

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