Issue 29, 2016
From the journal:

RSC Advances

Potassium carbonate-mediated tandem C–S and C–N coupling reaction for the synthesis of phenothiazines under transition-metal-free and ligand-free conditions†

San Wu,a   Wei-Ye Hua  and  Song-Lin Zhang*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
E-mail: zhangsl@suda.edu.cn

Abstract

An efficient potassium carbonate-mediated tandem C–S and C–N coupling reaction between N-(2-iodophenyl)acetamides and 2-halo-benzenethiols has been developed. This protocol affords a simple and efficient approach for the construction of phenothiazine derivatives without the need for addition of transition-metal catalyst or ligand for the first time. Furthermore, the reaction can be easily performed on a large scale.

Graphical abstract: Potassium carbonate-mediated tandem C–S and C–N coupling reaction for the synthesis of phenothiazines under transition-metal-free and ligand-free conditions

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Article information

DOI
https://doi.org/10.1039/C6RA01295G
Article type
Communication
Submitted
15 Jan 2016
Accepted
23 Feb 2016
First published
25 Feb 2016

RSC Adv., 2016,6, 24257-24260

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Potassium carbonate-mediated tandem C–S and C–N coupling reaction for the synthesis of phenothiazines under transition-metal-free and ligand-free conditions

S. Wu, W. Hu and S. Zhang, RSC Adv., 2016, 6, 24257 DOI: 10.1039/C6RA01295G

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