First double hydrophilic graft copolymer bearing a poly(2-hydroxylethyl acrylate) backbone synthesized by sequential RAFT polymerization and SET-LRP

Yinan Cui; Xiuyu Jiang; Chun Feng; Guangxin Gu; Jie Xu; Xiaoyu Huang

doi:10.1039/C6PY00489J

First double hydrophilic graft copolymer bearing a poly(2-hydroxylethyl acrylate) backbone synthesized by sequential RAFT polymerization and SET-LRP†

Yinan Cui,‡^a Xiuyu Jiang,‡^a Chun Feng,^a Guangxin Gu,*^b Jie Xu^b and Xiaoyu Huang*^a

* Corresponding authors

^a Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China
E-mail: xyhuang@mail.sioc.ac.cn
Fax: +86-21-64166128
Tel: +86-21-54925310

^b Department of Materials Science, Fudan University, 220 Handan Road, Shanghai 200433, People's Republic of China
E-mail: guangxingu@fudan.edu.cn
Fax: +86-21-65649937
Tel: +86-21-55664033

Abstract

Two well-defined double hydrophilic graft copolymers comprising a hydrophilic poly(2-hydroxyethyl acrylate) (PHEA) backbone and hydrophilic poly(N-isopropylacrylamide) (PNIPAM) side chains were synthesized by the combination of reversible addition–fragmentation chain transfer (RAFT) polymerization, single-electron-transfer living radical polymerization (SET-LRP), and a grafting-from strategy. A 2-hydroxyethyl 2-((2-chloropropanoyloxy)methyl)acrylate monomer containing an SET-LRP initiating group (–OCOCH(CH₃)Cl) was first RAFT homopolymerized to provide a PHEA-based homopolymer bearing a Cl-containing SET-LRP initiating group in every repeated unit with a narrow molecular weight distribution (M_w/M_n = 1.17). This homopolymer directly initiated SET-LRP of N-isopropylacrylamide at ambient temperature to afford the desired well-defined poly(2-hydroxyethyl acrylate)-graft-poly(N-isopropylacrylamide) graft copolymers (M_w/M_n ≤ 1.33) with hydroxyl in every repeated unit of the backbone without polymeric functionality transformation. The thermo-responsive phase behavior of the obtained double hydrophilic graft copolymers was investigated by UV/vis spectroscopy, ¹H NMR, and dynamic light scattering (DLS).

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DOI: https://doi.org/10.1039/C6PY00489J
Article type: Paper
Submitted: 18 Mar 2016
Accepted: 07 Apr 2016
First published: 07 Apr 2016
This article is Open Access

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Polym. Chem., 2016,7, 3156-3164

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First double hydrophilic graft copolymer bearing a poly(2-hydroxylethyl acrylate) backbone synthesized by sequential RAFT polymerization and SET-LRP

Y. Cui, X. Jiang, C. Feng, G. Gu, J. Xu and X. Huang, Polym. Chem., 2016, 7, 3156 DOI: 10.1039/C6PY00489J

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Polymer Chemistry

First double hydrophilic graft copolymer bearing a poly(2-hydroxylethyl acrylate) backbone synthesized by sequential RAFT polymerization and SET-LRP†

Abstract

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First double hydrophilic graft copolymer bearing a poly(2-hydroxylethyl acrylate) backbone synthesized by sequential RAFT polymerization and SET-LRP

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