Issue 42, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids†

Jian Gua  and  Chun Cai*a  

* Corresponding authors

a Chemical Engineering College, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210094, People's Republic of China
E-mail: c.cai@njust.edu.cn

Abstract

A copper mediated radical oxidative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids is developed. This study offers a new and expedient strategy for the synthesis of useful indolizines in moderate to good yields and exhibits a broad substrate scope and good functional group tolerance.

Graphical abstract: Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids

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Article information

DOI
https://doi.org/10.1039/C6OB01902A
Article type
Communication
Submitted
29 Aug 2016
Accepted
30 Sep 2016
First published
30 Sep 2016

Org. Biomol. Chem., 2016,14, 9966-9969

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Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids

J. Gu and C. Cai, Org. Biomol. Chem., 2016, 14, 9966 DOI: 10.1039/C6OB01902A

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