Issue 20, 2016
From the journal:

Organic & Biomolecular Chemistry

Amino acid-promoted C–H alkylation with alkylboronic acids using a removable directing group†

Yu Zhang,a   Hang Jiang,a   Dushen Chena  and  Yanghui Zhang*a  

* Corresponding authors

a Department of Chemistry, and Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. China
E-mail: zhangyanghui@tongji.edu.cn

Abstract

Palladium-catalyzed C–H alkylation reaction with alkylboronic acids has successfully been developed using a removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The alkylation protocol is also applicable to the coupling of C(sp3)–H bonds with alkylboronic acids.

Graphical abstract: Amino acid-promoted C–H alkylation with alkylboronic acids using a removable directing group

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Article information

DOI
https://doi.org/10.1039/C6OB00674D
Article type
Communication
Submitted
30 Mar 2016
Accepted
25 Apr 2016
First published
26 Apr 2016

Org. Biomol. Chem., 2016,14, 4585-4589

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Amino acid-promoted C–H alkylation with alkylboronic acids using a removable directing group

Y. Zhang, H. Jiang, D. Chen and Y. Zhang, Org. Biomol. Chem., 2016, 14, 4585 DOI: 10.1039/C6OB00674D

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