Research highlights: examining the effect of shape on nanoparticle interactions with organisms

Joseph T. Buchman; Miranda J. Gallagher; Chi-Ta Yang; Xi Zhang; Miriam O. P. Krause; Rigoberto Hernandez; Galya Orr

doi:10.1039/C6EN90015A

Research highlights: examining the effect of shape on nanoparticle interactions with organisms

Joseph T. Buchman,*^a Miranda J. Gallagher,^b Chi-Ta Yang,^c Xi Zhang,^d Miriam O. P. Krause,^e Rigoberto Hernandez^f and Galya Orr^g

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* Corresponding authors

^a Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
E-mail: jbuchman@umn.edu

^b Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA

^c Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA

^d Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

^e Center for Sustainable Nanotechnology, Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA

^f School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA

^g Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA

Abstract

There are many variables that influence the toxicity of nanoparticles to organisms, such as nanoparticle size, shape, core composition, and ligand chemistry, composition, and coverage. Assessing the unique effects elicited by each of these parameters has been challenging as they impact each other. It is therefore difficult to change one parameter while keeping all other parameters constant. Here, we highlight three articles in which investigators carefully controlled as many confounding factors as possible while assessing the impacts of nanoparticle shape on their interactions with organisms. One study revealed shape-dependent effects of silver nanoparticles on the annual ryegrass, Lolium multiflorum. Another study identified shape-dependent effects of lanthanide-doped NaYF₄ nanoparticles on nanoparticle association with a model cell membrane and on the cellular uptake and toxicity in selected cell lines. Finally, we highlight a study that used a coarse grain computational approach to effectively keep other parameters constant while determining the effect of shape on nanoparticle endocytosis.

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https://doi.org/10.1039/C6EN90015A

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First published

19 Jul 2016

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Environ. Sci.: Nano, 2016,3, 696-700

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Research highlights: examining the effect of shape on nanoparticle interactions with organisms

J. T. Buchman, M. J. Gallagher, C. Yang, X. Zhang, M. O. P. Krause, R. Hernandez and G. Orr, Environ. Sci.: Nano, 2016, 3, 696 DOI: 10.1039/C6EN90015A

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Environmental Science: Nano

Research highlights: examining the effect of shape on nanoparticle interactions with organisms

Abstract

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Research highlights: examining the effect of shape on nanoparticle interactions with organisms

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