The enthalpy–entropy compensation was observed for the cooperative 1^A/LS → 1^A/HS spin transition (the phase 1^A is a mononuclear complex [FeL₂](BF₄)₂, L is 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(pyridin-2-yl)-6-methylpyrimidine). The physical origin of this effect is the fact that the 1^A/LS → 1^A/HS spin transition is the first order phase transition accompanied by noticeable variations in the T_onset↑, ΔH and ΔS values. Higher ΔH and ΔS values are correlated with higher T_onset↑ values. The higher the enthalpy and entropy of the spin transition, the wider the hysteresis loop. The kinetic compensation effect, i.e. a linear relationship between ln A and E_a, was observed for the 1^A/LS → 1^A/HS spin transition. Moreover, an isokinetic relationship was detected in this system: the Arrhenius lines (ln k vs. 1/T) obtained from magnetochemical data for different samples of the phase 1^A undergoing the 1^A/LS → 1^A/HS transition show a common point of intersection (T_iso = 490 ± 2 K, ln k_iso = −6.0 ± 0.2). The validity of this conclusion was confirmed by the Exner–Linert statistical method. This means that the isokinetic relationship and the kinetic compensation effect (ln A vs. E_a) in this system are true ones. The existence of a true kinetic compensation effect is supported independently by the fact that the hysteresis loop width for the cooperative spin transition 1^A/LS ↔ 1^A/HS increases with increasing activation barrier height. Estimating the energy of excitations for the phase 1^A/LS with T_iso ∼ 490 K yields wavenumbers of ca. 340 cm⁻¹ corresponding to the frequencies of the stretching vibrations of the Fe^LS–N bonds, i.e. the bonds directly involved in the mechanism of the spin transition. This is the first observation of the kinetic compensation effect (ln A vs. E_a) and the isokinetic relationship for a cooperative spin crossover system showing thermal hysteresis. Our results provide the first experimental evidence that the higher the activation barrier for the spin transition, the wider the hysteresis loop for a series of related spin crossover systems.