Issue 71, 2016
From the journal:

Chemical Communications

Heterodinuclear Pt(iv)–Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis†

Lili Ma,a   Rong Ma,a   Zhigang Wang,a   Shek-Man Yiua  and  Guangyu Zhu*ab  

* Corresponding authors

a Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Ave, Hong Kong SAR, China
E-mail: guangzhu@cityu.edu.hk

b City University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China

Abstract

A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(IV)–Ru(II) heterodinuclear complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.

Graphical abstract: Heterodinuclear Pt(iv)–Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis

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Article information

DOI
https://doi.org/10.1039/C6CC04354B
Article type
Communication
Submitted
24 May 2016
Accepted
02 Aug 2016
First published
02 Aug 2016

Chem. Commun., 2016,52, 10735-10738

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Heterodinuclear Pt(IV)–Ru(II) anticancer prodrugs to combat both drug resistance and tumor metastasis

L. Ma, R. Ma, Z. Wang, S. Yiu and G. Zhu, Chem. Commun., 2016, 52, 10735 DOI: 10.1039/C6CC04354B

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