Issue 1, 2017
From the journal:

Biomaterials Science

Fabricating polyacrylamide microbeads by inverse emulsification to mimic the size and elasticity of living cells†

Nicholas R. Labriola,a   Edith Mathiowitzb  and  Eric M. Darling ORCID logo *bc  

* Corresponding authors

a Center for Biomedical Engineering, Brown University, Providence, RI 02912, USA

b Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA

c School of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02906, USA
E-mail: Eric_Darling@brown.edu
Fax: +1 401 863 1595
Tel: +1 401 863 6818

Abstract

Inverse emulsification was used to fabricate polyacrylamide (PAAm) microbeads with size and elastic properties similar to typical, mammalian cells. These biomimicking microbeads could be fluorescently stained and functionalized with a collagen type-I coating, post-polymerization, for tracking bead locations and promoting cell recognition/binding, respectively. By occupying a previously unfilled range of sizes and mechanical properties, these microbeads may find unique use in both biomedical and materials applications.

Graphical abstract: Fabricating polyacrylamide microbeads by inverse emulsification to mimic the size and elasticity of living cells

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Article information

DOI
https://doi.org/10.1039/C6BM00692B
Article type
Communication
Submitted
29 Sep 2016
Accepted
03 Dec 2016
First published
09 Dec 2016

Biomater. Sci., 2017,5, 41-45

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Fabricating polyacrylamide microbeads by inverse emulsification to mimic the size and elasticity of living cells

N. R. Labriola, E. Mathiowitz and E. M. Darling, Biomater. Sci., 2017, 5, 41 DOI: 10.1039/C6BM00692B

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