Issue 19, 2016

Solvent strategy for unleashing the Lewis acidity of titanocene dichloride for rapid Mannich reactions

Abstract

The remarkable activation effect of alcohol solvent on kinetically inert titanocene dichloride was found to promote rapid three-component Mannich reactions. NMR and ESI-MS analyses as well as a control experiment of catalytic active species elucidated that the coordination of MeOH to the titanocene moiety unleashed the Lewis acid [Cp2Ti(OMe)2] and Brønsted acid HCl, which led to the enhanced catalytic activity of [Cp2TiCl2].

Graphical abstract: Solvent strategy for unleashing the Lewis acidity of titanocene dichloride for rapid Mannich reactions

Supplementary files

Article information

Article type
Communication
Submitted
18 Dec 2015
Accepted
12 Jan 2016
First published
21 Jan 2016

RSC Adv., 2016,6, 15298-15303

Solvent strategy for unleashing the Lewis acidity of titanocene dichloride for rapid Mannich reactions

Y. Wu, X. Wang, Y. Luo, J. Wang, Y. Jian, H. Sun, G. Zhang, W. Zhang and Z. Gao, RSC Adv., 2016, 6, 15298 DOI: 10.1039/C5RA27094D

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