11C-carbonylation reactions using gas–liquid segmented microfluidics

Kenneth Dahl; Magnus Schou; Johan Ulin; Carl-Olof Sjöberg; Lars Farde; Christer Halldin

doi:10.1039/C5RA20646D

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¹¹C-carbonylation reactions using gas–liquid segmented microfluidics†

Kenneth Dahl,*^a Magnus Schou,^b Johan Ulin,^c Carl-Olof Sjöberg,^c Lars Farde^ab and Christer Halldin^a

Author affiliations

* Corresponding authors

^a Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, S-171 76 Stockholm, Sweden
E-mail: Kenneth.dahl@ki.se

^b AstraZeneca Translational Science Centre, Department of Clinical Neuroscience, Karolinska Institutet, S-171 76 Stockholm, Sweden

^c Bencar AB, Uppsala Science Park, S-751 83 Uppsala, Sweden

Abstract

A novel gas–liquid segmented microfluidic platform has been developed. The Pd-mediated ¹¹C-carbonylation reaction proceeds smoothly on this platform and good to excellent radiochemical conversions (RCC) were observed. Twelve compounds were successfully radiolabelled using this novel technology, including the well established D₂ receptor radioligands [¹¹C]raclopride and [¹¹C]FLB 457.

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Article information

DOI: https://doi.org/10.1039/C5RA20646D
Article type: Communication
Submitted: 31 Aug 2015
Accepted: 12 Oct 2015
First published: 20 Oct 2015
This article is Open Access

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RSC Adv., 2015,5, 88886-88889

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¹¹C-carbonylation reactions using gas–liquid segmented microfluidics

K. Dahl, M. Schou, J. Ulin, C. Sjöberg, L. Farde and C. Halldin, RSC Adv., 2015, 5, 88886 DOI: 10.1039/C5RA20646D

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