Issue 111, 2015
From the journal:

RSC Advances

Structurally novel C17-sesquiterpene lactones from Ainsliaea pertyoides†

Zhi-Ran Shi,ab   Yun-Heng Shen,*b   Xian-Yuan Zhang,c   Xin Fang,b   Ren-Tao Zeng,b   Qing-Xin Liu,ab   Zhi-Guo Zhuo,b   Feng Feng*a  and  Wei-Dong Zhang*abc  

* Corresponding authors

a Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: fengsunlight@163.com, wdzhangy@hotmail.com

b Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China
E-mail: shenyunheng@hotmail.com

c Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, P. R. China

Abstract

Pertyolides A (1) and B (2), two unprecedented C17-eudesmanolides with extended side chains, and one rare C17-guaianolide, pertyolide C (3), along with 15 known sesquiterpene lactones were isolated from the whole plant of Ainsliaea pertyoides. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of compound 1 was assigned by X-ray crystallography. All isolates were evaluated for their cytotoxic activities against four human tumor cell lines A549, HCT116, MGC803, CCRF-CEM, and only alantolactone (5) showed significant inhibitions against the tumor cell lines tested.

Graphical abstract: Structurally novel C17-sesquiterpene lactones from Ainsliaea pertyoides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5RA16551B
Article type
Communication
Submitted
17 Aug 2015
Accepted
15 Oct 2015
First published
16 Oct 2015

RSC Adv., 2015,5, 91640-91644

Permissions

Request permissions

Structurally novel C17-sesquiterpene lactones from Ainsliaea pertyoides

Z. Shi, Y. Shen, X. Zhang, X. Fang, R. Zeng, Q. Liu, Z. Zhuo, F. Feng and W. Zhang, RSC Adv., 2015, 5, 91640 DOI: 10.1039/C5RA16551B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements