Heparin-modified graphene oxide loading anti-cancer drug and growth factor with heat stability, long-term release property and lower cytotoxicity

Ting Wu; Bin Zhang; Yuanyuan Liang; Tao Liu; Jinyan Bu; Lixing Lin; Zhimin Wu; Hongxi Liu; Shuiping Wen; Shaozao Tan; Xiang Cai

doi:10.1039/C5RA14203B

Heparin-modified graphene oxide loading anti-cancer drug and growth factor with heat stability, long-term release property and lower cytotoxicity

Ting Wu,^a Bin Zhang,^b Yuanyuan Liang,^cd Tao Liu,*^e Jinyan Bu,^a Lixing Lin,^a Zhimin Wu,^a Hongxi Liu,^a Shuiping Wen,^a Shaozao Tan^b and Xiang Cai*^a

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^a Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, P. R. China
E-mail: cecaixiang@163.com
Fax: +86 0757 83106906
Tel: +86 0757 83106906

^b Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China

^c College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, P. R. China

^d College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China

^e Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou, P. R. China
E-mail: taoliu18@126.com

Abstract

To realize the long-term release property of drugs, reduce the cytotoxicity of anti-cancer drugs and improve the heat stability of the growth factor, a heparin-modified graphene oxide (Hep-GO) was prepared through a click reaction between azide-modified graphene oxide and propargylamine-modified heparin. Then, the Hep-GO was used as a carrier of doxorubicin hydrochloride (DOX) and granulocyte colony stimulating factor (G-CSF), and a Hep-GO/DOX/G-CSF complex was fabricated. UV-Vis analysis was carried out to study the colloidal stability of Hep-GO in aqueous solution. A thermogravimetric test was used to determine its composition. Then, the loading process, in vitro release behavior, heat stability and cytotoxicity of the Hep-GO/DOX/G-CSF complex were studied. The results showed that the Hep-GO/DOX/G-CSF complex displayed heat stability, long-term drug release property and lower drug cytotoxicity, suggesting the great potential application of Hep-GO as a multifunctional drug delivery system.

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Heparin-modified graphene oxide loading anti-cancer drug and growth factor with heat stability, long-term release property and lower cytotoxicity

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Heparin-modified graphene oxide loading anti-cancer drug and growth factor with heat stability, long-term release property and lower cytotoxicity

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