Issue 98, 2015
From the journal:

Chemical Communications

The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells†

Haijie Han,a   Qiao Jin,*a   Yin Wang,a   Yangjun Chena  and  Jian Ji*a  

* Corresponding authors

a MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
E-mail: jinqiao@zju.edu.cn, jijian@zju.edu.cn

Abstract

An enzyme and reduction-activatable gemcitabine prodrug (TPE-GEM-RGD) with aggregation-induced emission (AIE) properties was designed for targeted and image-guided cancer therapy. TPE-GEM-RGD was successfully used for intracellular light-up imaging and glutathione (GSH)-responsive release of gemcitabine to suppress pancreatic cancer cells.

Graphical abstract: The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells

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Article information

DOI
https://doi.org/10.1039/C5CC06654A
Article type
Communication
Submitted
08 Aug 2015
Accepted
05 Oct 2015
First published
05 Oct 2015

Chem. Commun., 2015,51, 17435-17438

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The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells

H. Han, Q. Jin, Y. Wang, Y. Chen and J. Ji, Chem. Commun., 2015, 51, 17435 DOI: 10.1039/C5CC06654A

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