Issue 28, 2015
From the journal:

RSC Advances

Synthetic application of gold nanoparticles and auric chloride for the synthesis of 5-substituted 1H-tetrazoles†

Satyanand Kumar,a   Arvind Kumar,a   Alka Agarwal*b  and  Satish Kumar Awasthi*a  

* Corresponding authors

a Chemical Biology Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India
E-mail: satishpna@gmail.com
Tel: +91 1127666646 ext. 121, 134

b Department of Medicinal Chemistry, IMS, BHU, Varanasi-221005, India
E-mail: alka_ag_2000@yahoo.com
Tel: +91 9453048577

Abstract

An effective one-pot, convenient gold catalyzed synthesis of 5-substituted 1H-tetrazoles has been discussed. The study demonstrated the comparative overview for utilization of gold(III) and gold nano-particles (spheres) as a catalyst. Detailed understandings of the mechanism, surface area effect (in reference to nanoparticles) of gold in the activation of nitriles for nucleophilic (3 + 2) cycloaddition of sodium azide to give the product have also been studied.

Graphical abstract: Synthetic application of gold nanoparticles and auric chloride for the synthesis of 5-substituted 1H-tetrazoles

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Article information

DOI
https://doi.org/10.1039/C4RA13461C
Article type
Paper
Submitted
30 Oct 2014
Accepted
10 Feb 2015
First published
13 Feb 2015

RSC Adv., 2015,5, 21651-21658

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Synthetic application of gold nanoparticles and auric chloride for the synthesis of 5-substituted 1H-tetrazoles

S. Kumar, A. Kumar, A. Agarwal and S. K. Awasthi, RSC Adv., 2015, 5, 21651 DOI: 10.1039/C4RA13461C

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