Issue 2, 2015

The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Abstract

The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

Graphical abstract: The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Supplementary files

Article information

Article type
Communication
Submitted
24 Sep 2014
Accepted
15 Oct 2014
First published
15 Oct 2014

Org. Biomol. Chem., 2015,13, 365-368

Author version available

The direct electrophilic cyanation of β-keto esters and amides with cyano benziodoxole

Y. Wang, J. Qiu, D. Kong, Y. Gao, F. Lu, P. G. Karmaker and F. Chen, Org. Biomol. Chem., 2015, 13, 365 DOI: 10.1039/C4OB02032D

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