Issue 14, 2014
From the journal:

Organic & Biomolecular Chemistry

Straightforward access to 4-membered sulfurated heterocycles: introducing a strategy for the single and double functionalization of thietane 1-oxide†

Laura Carroccia,a   Leonardo Degennaro,a   Giuseppe Romanazzi,b   Corrado Cuocci,c   Luisa Pisanod  and  Renzo Luisi*a  

* Corresponding authors

a Department of Pharmacy – Drug Sciences, University of Bari “A. Moro”, Via E. Orabona 4, Bari 70125 – I, Italy
E-mail: renzo.luisi@uniba.it

b DICATECh, Polytechnic of Bari, Via E. Orabona 4, Bari 70125 – I, Italy

c Istituto di Cristallografia (IC-CNR), Via Amendola 122/o, 70125 Bari – I, Italy

d Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari – I, Italy

Abstract

A strategy for the stereoselective functionalization of thietane 1-oxide has been developed. Mono (C2 substituted) and doubly (C2, C4 disubstituted) functionalized thietanes have been obtained from the readily available thietane 1-oxide by using the corresponding organometallic intermediates that reacted with electrophiles leaving intact the 4-membered ring.

Graphical abstract: Straightforward access to 4-membered sulfurated heterocycles: introducing a strategy for the single and double functionalization of thietane 1-oxide

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Article information

DOI
https://doi.org/10.1039/C4OB00173G
Article type
Communication
Submitted
22 Jan 2014
Accepted
11 Feb 2014
First published
12 Feb 2014

Org. Biomol. Chem., 2014,12, 2180-2184

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Straightforward access to 4-membered sulfurated heterocycles: introducing a strategy for the single and double functionalization of thietane 1-oxide

L. Carroccia, L. Degennaro, G. Romanazzi, C. Cuocci, L. Pisano and R. Luisi, Org. Biomol. Chem., 2014, 12, 2180 DOI: 10.1039/C4OB00173G

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