Nickel nanoparticles assisted regioselective synthesis of pyrazoloquinolinone and triazoloquinazolinone derivatives†
Abstract
Biologically important pyrazoloquinolinone and triazoloquinazolinone derivatives were synthesized by the condensation reaction of 3-amino-1H-1,2,4-triazole/3-amino-5-methyl-1H-pyrazole, dimedone and aryl aldehydes using catalytic amount of magnetically retrievable nickel nanoparticles under reflux condition. This protocol eliminates the usage of toxic reagents, complex work-up conditions, etc., with the added benefit of reusability of the catalyst without compromising the yield or purity of the product.
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