Issue 10, 2014
From the journal:

Biomaterials Science

Graphene oxide modified with aptamer-conjugated gold nanoparticles and heparin: a potent targeted anticoagulant†

Yi-Heng So,a   Huan-Tsung Chang,b   Wei-Jane Chiua  and  Chih-Ching Huang*acd  

* Corresponding authors

a Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
E-mail: huanging@ntou.edu.tw
Fax: +011-886-2-2462-2320
Tel: +011-886-2-2462-2192 ext. 5517

b Department of Chemistry, National Taiwan University, Taipei, Taiwan

c Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, Taiwan

d School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Graphene oxide (GO) modified with 29-mer thrombin-binding-aptamer-conjugated gold nanoparticles (TBA29–Au NPs/GO) can synergistically inhibit the thrombin-mediated cleavage of fibrinogen to fibrin. To further improve anticoagulation efficiency in human plasma, TBA29–Au NPs/heparin/GO has been prepared from TBA29–Au NPs/GO and heparin that can also bind thrombin. The dose-dependence of thrombin clotting time (TCT) delay caused by TBA29–Au NPs/heparin/GO is 21.4, 17.0 and >100 times higher than that caused by the TBA29–Au NPs, TBA29–Au NPs/GO and commercially available drugs (heparin, argatroban, hirudin or warfarin), respectively.

Graphical abstract: Graphene oxide modified with aptamer-conjugated gold nanoparticles and heparin: a potent targeted anticoagulant

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4BM00156G
Article type
Communication
Submitted
03 May 2014
Accepted
11 Jul 2014
First published
23 Jul 2014

Biomater. Sci., 2014,2, 1332-1337

Author version available

Download author version (PDF)

Permissions

Request permissions

Graphene oxide modified with aptamer-conjugated gold nanoparticles and heparin: a potent targeted anticoagulant

Y. So, H. Chang, W. Chiu and C. Huang, Biomater. Sci., 2014, 2, 1332 DOI: 10.1039/C4BM00156G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements