Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate

M. Tijink; J. Janssen; M. Timmer; J. Austen; Y. Aldenhoff; J. Kooman; L. Koole; J. Damoiseaux; R. van Oerle; Y. Henskens; D. Stamatialis

doi:10.1039/C3TB20964D

Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate

M. Tijink,^a J. Janssen,^b M. Timmer,^a J. Austen,^c Y. Aldenhoff,^b J. Kooman,^d L. Koole,^ef J. Damoiseaux,^c R. van Oerle,^g Y. Henskens^h and D. Stamatialis*^a

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* Corresponding authors

^a Institute for biomedical technology and technical medicine MIRA, Biomaterials Science and Technology, University of Twente, Faculty of Science and Technology, P.O. Box 217, 7500 AE Enschede, The Netherlands
E-mail: d.stamatialis@utwente.nl
Fax: +31 53 4892155
Tel: +31 53 4894675

^b Interface BIOmaterials BV, Burg. Lemmensstraat 364, 6163 JT Geleen, The Netherlands

^c Department of Internal Medicine, Immunology laboratory, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands

^d Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands

^e Department of Biomedical Engineering/Biomaterials Science, Maastricht University, Faculty of Health, Medicine & Life Sciences, Maastricht, The Netherlands

^f University of Malaya, Department of Biomedical Engineering, Kuala Lumpur, Malaysia

^g Department of Internal Medicine, Clin. Thrombosis & Hemostasis laboratory, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands

^h Department of Internal Medicine, Central Diagnostic Laboratory, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands

Abstract

Developments in membrane based blood purification therapies often come with longer treatment times and therefore longer blood–material contact, which requires long-term membrane biocompatibility. In this study, we develop for the first time membranes for blood purification using the material SlipSkin™, which is a copolymer, made from N-vinylpyrrolidone (NVP) and butylmethacrylate (BMA). Specific attention is focused on understanding the mechanism of pore formation and the tailoring of the membrane mechanical and transport properties to obtain the optimal membrane for blood purification therapies. Polymer composition, solvent type and solvent evaporation time influence membrane morphology and membranes with sieving properties of cascade filters in plasma fractionation applications are developed. The new membranes have very good blood compatibility properties; in fact compared to benchmark flat membranes currently used in the clinic, they have lower platelet adhesion while all other properties (contact activation, thrombogenicity, leukocyte adhesion, hemolysis and complement activation) are also very good and comparable to the benchmarks.

Journal of Materials Chemistry B

Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate

Abstract

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Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate

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