Issue 20, 2013
From the journal:

Journal of Materials Chemistry B

The preparation and drug delivery of a graphene–carbon nanotube–Fe3O4nanoparticle hybrid†

Xiujuan Fan,a   Guozheng Jiao,a   Lei Gao,c   Pengfei Jina  and  Xin Li*ab  

* Corresponding authors

a Department of Chemistry, Harbin Institute of Technology, Harbin 150090, China
E-mail: lixin@hit.edu.cn
Fax: +86 451 86418750
Tel: +86 451 86282153

b State Key Lab of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China

c Electron Microscopy Centre, Harbin Medical University, Harbin 150086, China

Abstract

We report a green and facile procedure of synthesizing a graphene nanosheet–carbon nanotube–iron oxide nanoparticle hybrid (GN–CNT–Fe3O4) as a promising platform for the loading and delivery of anticancer drugs. The obtained GN–CNT–Fe3O4 hybrid exhibited superparamagnetic properties with the saturation magnetization of 19.824 emu g−1. This hybrid nanostructure possesses a superior capability of binding the anticancer drug 5-fluorouracil (5-FU) with a high loading capacity of up to 0.27 mg mg−1 with a 5-FU concentration of 0.5 mg mL−1, and also possesses a pH-activated release profile. Moreover, cellular uptake studies show that the resulting GN–CNT–Fe3O4 hybrid can be internalized efficiently by HepG2 cells. In vitro cytotoxicity tests suggest that the obtained GN–CNT–Fe3O4 hybrid is nontoxic for Chang liver cells, even at the high concentration of 80 μg mL−1, however, the 5-FU-loaded GN–CNT–Fe3O4 hybrid showed significant cytotoxic effects in HepG2 cells. The results show that this novel 3D hybrid is a promising candidate for anti-cancer drug delivery systems.

Graphical abstract: The preparation and drug delivery of a graphene–carbon nanotube–Fe3O4 nanoparticle hybrid

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Article information

DOI
https://doi.org/10.1039/C3TB00493G
Article type
Paper
Submitted
06 Dec 2012
Accepted
12 Mar 2013
First published
13 Mar 2013

J. Mater. Chem. B, 2013,1, 2658-2664

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The preparation and drug delivery of a graphene–carbon nanotube–Fe3O4 nanoparticle hybrid

X. Fan, G. Jiao, L. Gao, P. Jin and X. Li, J. Mater. Chem. B, 2013, 1, 2658 DOI: 10.1039/C3TB00493G

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