Issue 39, 2013
From the journal:

Organic & Biomolecular Chemistry

Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies†

Dalip Kumar,*a   Bhupendra A. Mishra,a   K. P. Chandra Shekar,a   Anil Kumar,a   Kanako Akamatsu,b   Ryohsuke Kuriharab  and  Takeo Ito*b  

* Corresponding authors

a Department of Chemistry, Birla Institute of Technology & Science, Pilani-333 031, India
E-mail: dalipk@pilani.bits-pilani.ac.in
Fax: +91-1596-244183
Tel: +91-1596-245073-5238

b Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
E-mail: takeoit@scl.kyoto-u.ac.jp

Abstract

A Cu(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin–psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).

Graphical abstract: Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

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Article information

DOI
https://doi.org/10.1039/C3OB41224E
Article type
Communication
Submitted
13 Jun 2013
Accepted
26 Jul 2013
First published
29 Jul 2013

Org. Biomol. Chem., 2013,11, 6675-6679

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Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

D. Kumar, B. A. Mishra, K. P. Chandra Shekar, A. Kumar, K. Akamatsu, R. Kurihara and T. Ito, Org. Biomol. Chem., 2013, 11, 6675 DOI: 10.1039/C3OB41224E

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