Issue 34, 2013
From the journal:

Dalton Transactions

A mitochondria-specific visible-light sensitized europium β-diketonate complex with red emission†

V. Divya,a   Vandana Sankar,b   K. G. Raghub  and  M. L. P. Reddy*a  

* Corresponding authors

a Chemical Sciences and Technology Division, CSIR-Network of Institutes for Solar Energy, National Institute for Interdisciplinary Science & Technology (NIIST), CSIR, Thiruvananthapuram-695 019, India
E-mail: mlpreddy55@gmail.com

b Agroprocessing and Natural Products, National Institute for Interdisciplinary Science & Technology (NIIST), CSIR, Thiruvananthapuram-695019, India

Abstract

Our recently developed Eu3+ coordination compound, Eu(pfppd)3(tpy) [where Hpfppd = 4,4,5,5,5-pentafluoro-3-hydroxy-1-(phenanthren-3-yl)pentanedione and tpy = 2,2′:6,6′′-terpyridine] exhibits significant quantum yield (Φoverall = 41%) and long 5D0 lifetime (880 μs) values under biologically relevant pH conditions (pH = 7.4) when excited with visible light. Hence, the Eu3+ luminescent complex was examined for live cell imaging using the rat embryonic heart cell line, H9c2. The ternary Eu3+ complex permeates into the H9c2 cells and co-localises with the mitochondria, as demonstrated by counterstaining experiments. Furthermore, the designed Eu3+ bioprobe remains undissociated in the cell medium, showed a good cell permeability and a fast cellular uptake with a specific localization profile. Thus it has the potential to become a time-resolved imaging probe that is excitable in the visible-light range.

Graphical abstract: A mitochondria-specific visible-light sensitized europium β-diketonate complex with red emission

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3DT51117K
Article type
Paper
Submitted
01 May 2013
Accepted
05 Jun 2013
First published
06 Jun 2013

Dalton Trans., 2013,42, 12317-12323

Permissions

Request permissions

A mitochondria-specific visible-light sensitized europium β-diketonate complex with red emission

V. Divya, V. Sankar, K. G. Raghu and M. L. P. Reddy, Dalton Trans., 2013, 42, 12317 DOI: 10.1039/C3DT51117K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements