Issue 24, 2013
From the journal:

Dalton Transactions

Novel tetranuclear triarylantimony(v) complexes with (±)-mandelic acid ligands: synthesis, characterization, in vitro cytotoxicity and DNA binding properties†

Jin Jiang,a   Handong Yin,*a   Fangli Wang,a   Zhong Han,a   Fei Wang,a   Shuang Chengb  and  Min Hong*ac  

* Corresponding authors

a Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, P. R. China
E-mail: handongyin@163.com, hongminlcu@163.com
Fax: (+)86 635 8239121

b School of Agriculture, Liaocheng University, Liaocheng, P. R. China

c State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, China

Abstract

Four novel tetranuclear organoantimony(V) complexes [R3SbL]4, in which LH = (±)-mandelic acid and R = phenyl (1), 4-fluorophenyl (2), 3-fluorophenyl (3), 3,4,5-trifluorophenyl (4), were synthesized and characterized. The complexes displayed rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells and efficient CT-DNA binding.

Graphical abstract: Novel tetranuclear triarylantimony(v) complexes with (±)-mandelic acid ligands: synthesis, characterization, in vitro cytotoxicity and DNA binding properties

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Article information

DOI
https://doi.org/10.1039/C3DT50221J
Article type
Communication
Submitted
22 Jan 2013
Accepted
16 Apr 2013
First published
17 Apr 2013

Dalton Trans., 2013,42, 8563-8566

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Novel tetranuclear triarylantimony(V) complexes with (±)-mandelic acid ligands: synthesis, characterization, in vitro cytotoxicity and DNA binding properties

J. Jiang, H. Yin, F. Wang, Z. Han, F. Wang, S. Cheng and M. Hong, Dalton Trans., 2013, 42, 8563 DOI: 10.1039/C3DT50221J

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