Issue 39, 2013
From the journal:

CrystEngComm

Two polymorphs and one hydrate of a molecular salt involving phenazopyridine and salicylic acid†

Qian Tao,a   Jia-Mei Chen*a  and  Tong-Bu Lub  

* Corresponding authors

a School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
E-mail: chenjm37@mail.sysu.edu.cn
Tel: +86-20-39943081

b MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/State Key Laboratory of Optoelectronic Materials and Technologies/School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

Abstract

Two anhydrous polymorphs (AH-I, AH-II) and one monohydrate (MH) of a molecular salt involving phenazopyridine and salicylic acid, are reported. The charge-assisted N–H⋯O hydrogen bond provides the main driving force for the direct binding of the two compounds. AH-I is the stable anhydrous form with a low hygroscopicity, a high solubility and a simple preparation method.

Graphical abstract: Two polymorphs and one hydrate of a molecular salt involving phenazopyridine and salicylic acid

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Article information

DOI
https://doi.org/10.1039/C3CE41188E
Article type
Communication
Submitted
20 Jun 2013
Accepted
07 Aug 2013
First published
08 Aug 2013

CrystEngComm, 2013,15, 7852-7855

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Two polymorphs and one hydrate of a molecular salt involving phenazopyridine and salicylic acid

Q. Tao, J. Chen and T. Lu, CrystEngComm, 2013, 15, 7852 DOI: 10.1039/C3CE41188E

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