Issue 24, 2014
From the journal:

Chemical Communications

Cu-catalyzed amidation of halogenated imidazoles†

Mo Wang,a   Zhenfeng Zhang,*b   Fang Xiea  and  Wanbin Zhang*ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
E-mail: wanbin@sjtu.edu.cn
Fax: +86 02154743265
Tel: +86 02154743265

b School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China

Abstract

An efficient methodology involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcohols.

Graphical abstract: Cu-catalyzed amidation of halogenated imidazoles

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Article information

DOI
https://doi.org/10.1039/C3CC49107B
Article type
Communication
Submitted
29 Nov 2013
Accepted
17 Jan 2014
First published
22 Jan 2014

Chem. Commun., 2014,50, 3163-3165

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Cu-catalyzed amidation of halogenated imidazoles

M. Wang, Z. Zhang, F. Xie and W. Zhang, Chem. Commun., 2014, 50, 3163 DOI: 10.1039/C3CC49107B

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